Yesterday I blogged about attempting the combo of Zyrtec & Pepcid AC to see if it would help my chronic cholinergic urticaria. The main reasoning behind this is that one is an H1 blocker, and the other an H2 blocker. This is supposed to be more effective than just using 1 type in some cases (not all), and I had never used it up to this point.
So since everyone’s cholinergic urticaria is different, I always recommend trying different antihistamine combinations to see if it can help manage your hives. I had never tried this, and wanted to see the results. I used a regular 10mg Zyrtec, and a regular pepcid ac. Again, please always talk to a doctor before trying this always (it may be dangerous for some people, especially if you are pregnant or have other conditions).
Did Pepcid AC and Zyrtec Help My Chronic Cholinergic Urticaria?
Well, the results were really quite odd, and it surprised me. First, a regular strength Zyrtec will usually make me very drowsy by itself. Also, when I took a Pepcid AC by itself it too made me very slightly drowsy. However, when I took them both it didn’t make me drowsy at all (which really shocked me).
Unfortunately, I still did get itchy a couple of times yesterday. The first time it just felt kind of uncomfortable, but I avoided an attack by cooling myself off with water. The second time I was playing basketball with my brother. Instead of a full attack, I just felt a few “stings.” They lasted for about 5 minutes. Later, I was able to fully sweat.
The sting felt more intense than usual, but wasn’t quite as itchy. So that was somewhat strange as well, and I suppose the H1 and H2 combo was slightly altering something during the actual histamine release phase.
Overall, I would say that it did somewhat help, but certainly not enough to justify taking it regularly. If I could put it in a percentage, I would say it helps about 50%. An antihistamine by itself helps between about 20-30% usually for me. So it helps a smidgen more, but not enough to really rely on it to knock the hives out 100%.
Let me put it this way: If I had to go publicly in front of a bunch of people in hot weather, I wouldn’t trust that combo to get me through it!
Again, you may want to try a few different combos under a doctors supervision to see if anything helps you. People with Cholinergic Urticaria really seem to react differently to different antihistamine treatments. Unfortunately, I am one of those “lucky” ones that seem to not get a lot of help from them at all.
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Posted under managing hives
This post was written by Ben on July 27, 2009

