To make a very long story short, I too, suffered from extreme chronic hives day and night. They just appeared out of nowhere. Before that, for as long as I can remember, I only got them from temperature extremes. (If I got too hot or cold or from excercise).
I went to doctors, had allergy tests, etc. I went on 4 different types of antihistamines. which only made it much worse. I did extensive research on histamine intolerance, chronic hives, etc.
Finally, I found a allergist that prescribed Doxepin, 10mg, 3 times a day. At first it made me so lethargic I couldn’t function. So, took 20mg. a night and the hives would just about disappear. I only got a few flat red splotches. So, I started taking the 30 mg every night and hives gone.
I changed my diet completely before getting on these meds, and still had hives. Anyway, Doxepin definitely did it!! No more suffering.
I read that a bad gut, such as too much of the bad bacteria could be a factor, so I started taking probiotics and amazingly the hives and red spots improved drastically. I have taken probiotics for over a month now, and feel I may be able to start decreasing the Doxepin and hopefully get off of it completely by another year. Probiotics really made a big difference for me.
I think hormones play a role in my hives. I am getting close to 50, so there are hormonal changes going on. I still don’t know the reason for the hives, but a lot of women seem to have new allergies and unexplained hives when they hit 40 and over.
I have noticed that although hives and red spots may be completely gone through out the month, when monthly cycle gets close, and hormone levels are changing, the red itchy spots start to appear and go away again after monthly cycle. So, could just be hormonal too.
I hope this helps you others out there with some answers.