Mast Cell Mediators and Histamine Receptors
Post by: nowash on September 04, 2011, 09:14:15 PM
Found this a couple of days ago. Thought it would shed light on some member’s CgU potentially causing acne.
As soon as I read this I upped my dose on loratadine and found I could eat sugar and eggs without getting acne.
Also turns out loratadine is metabolized through CYP3A6, meaning it could affect sex hormone levels. Wish that was on the box when you buy it. Also learned cimetidine and ranitidine increase serum prolactin levels, which I guess is how they can cause gynecomastia, maybe even ED. They inhibit some of the liver enzymes, too, and I wonder if that’s how it increases prolactin levels. Famotidine apparently has no effect on prolactin.
Ask me if you want references for those.
Title: List of mast cell mediators
Post by: nowash on September 04, 2011, 09:53:45 PM
This article was written by Dr. Theoharis Theoharides, whom does research on mastocytosis. The article is about migraines, but it has a list of mast cell mediators and their general actions. Not too sure if the list is comprehensive, but I’m sure he knows his stuff.
Off the top of my head, the mediators related to CgU that have been found are:
Not too sure about other ones, but I believe I’ve read that some eosinophil chemotactic factor is released as well. There also seems to be a systemic parasympathetic activation in some patients (tearing, asthma, diarrhea, salivation, abdominal cramping), but that’s not directly from mast cells. What chemical causes that? I don’t know, lest histamine causes the release of acetylcholine. I suppose we can put the leukotrienes in the above list since montelukast helps some people. Tryptase would be suspected as well since danazol increases a1-antichymotrypsin levels.