Vitamins and Supplements for Cholinergic Urticaria?
Post by: jga on June 09, 2008, 03:18:45 PM
NOTE: This page contains information and experiences about vitamins and supplements used in cholinergic urticaria. It is important to realize that it is never safe to take supplements without first consulting a doctor for proper dosages or to know if it is safe for you. This is not intended as medical advice, but rather, an online discussion of people relating what worked or didn’t work for them.
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Vitamin C is required for the formation of connective tissue and plays an important role in maintaining proper immune function central to the treatment of Hives. Several studies have suggested that Vitamin B12 may help reduce the frequency and severity of hives. Quercetin is a bioflavonoid which possesses beneficial antioxidant qualities which is useful in the treatment of Hives. Green Tea may be of benefit in the treatment of Hives because it contains the polyphenols epigallocatechin (EGC) and epicatechin gallate (ECG) that have been reported to have an antihistamine effect in vitro tests.
wonder how effective they would be if at all
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Title: Re: Vitamins?
Post by: billysielu on June 09, 2008, 11:53:26 PM
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*will pick up a multi-vitamin at the store later*
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Title: Re: Vitamins?
Post by: HivesGuy on June 10, 2008, 06:20:07 AM
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Thanks for the great post. I think it is definitely possible that there could be some sort of vitamin deficiency. I have tried a multivitamin before, and I really didn’t notice any improvements. I remember way back several months ago reading about some people with Cholinergic Urticaria that have been taking vitamins, trying acupuncture, & more, and it wasn’t really helping them much.
But it can’t hurt, and may be worth a shot for you to try them. Worst case scenario, they don’t help and you wasted $4. Best case scenario, it cures you–or at least maybe reduces the symptoms.
I just wished I knew whether or not this was some sort of deficiency in our diet/vitamin intake, or if it is just something genetic.
Since some people apparently get cured, it makes me think maybe it is something we can change/cure. But who knows…
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Title: Re: Vitamins?
Post by: billysielu on June 10, 2008, 11:40:46 AM
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i changed my mind, i dont want to be reliant on a tablet
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Title: Re: Vitamins?
Post by: HivesGuy on June 10, 2008, 04:51:03 PM
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Quote from: billysielu on June 10, 2008, 11:40:46 AM
i changed my mind, i dont want to be reliant on a tablet
Yeah, I know what you mean. It may be something everyone with Cholinergic Urticaria should try at some point just to rule it out as a possible solution, but I have already tried vitamins & it didn’t help at all. Plus I have heard others say it didn’t help as well. Let us know if it helps you any at all JGA.
But it does indeed stink having to rely on tablets. I just got through swallowing some generic lactose pills so I can eat pizza without getting bad stomach problems. YuCK! I hate taking any kind of medicine!
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Title: Re: Vitamins?
Post by: threesixmafia on June 11, 2008, 11:37:14 PM
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vitamin B6 and B12 keeps coming up as ones that help the most. 🙂 i would give them a try, can’t hurt to
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Title: Re: Vitamins?
Post by: jga on July 12, 2008, 11:18:01 PM
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I have noticed that a vitamin B supplement that I have been taking is a great help and can make sweating a lot easier. It’s cheap and easy to take, so I would definitely recommend that.
Vitamin B does come up a lot, need some of that
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Title: Effective Supplementation for Cholinergic Urticaria
Post by: whateverman on January 03, 2010, 09:22:38 AM
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I am a 20 year old male officially diagnosed with Cholinergic Urticaria. I’ve had the condition since about age 15. My hives appear as red, quarter-sized blotches all over my torso. Any activity that causes sweating seems to be the trigger. Rather than waste time lamenting how this has negatively effected my life, I’d prefer to talk about treatments.
Here is what I have tried, and my results with each:
1. Diphenhydramine hydrochloride (Benadryl) – OTC first-generation antihistamine. This works well in high enough doses, with numerous side effects. Effectiveness decreases with time. Consequently, this is not a permanent solution.
2. Cetirizine hydrochloride (Zyrtec) – I found this to be far less effective than Diphenhydramine, while still making me feel tired and “out of it.”
3. Strenuous exercise. This will always trigger an attack, causing the usual symptoms for about twenty minutes to an hour. Afterwards, there seems to be a cessation of hives for the rest of the day.
Like others, I have been unsatisfied with the results of each treatment. I quickly developed a tolerance to Benadryl, and was taking uncomfortably high doses for only a few hours relief. Zyrtec simply seemed to be a less effective alternative. Exercise was painful.
I am convinced the cause is dietary. If you are an American, your food supply has been completely adulterated. This is not to say healthy food is unavailable, but rather, the majority of food consumed by Americans today is absolutely terrible for you. This is why we have an obesity epidemic among numerous other systemic health problems in our population. If you live in the United States, you are likely to be unhealthy, because you have an unhealthy environment. Approximately two thirds of Americans are overweight. This is highly abnormal and should be a concern.
I am not a doctor. I am a computer science student. Do not follow this advice without consulting your doctor.
I’ve done some reading, and this is what I intend to do to cure my hives.
1. Vitamin D-3 supplementation (cholecalceferol).
2. Fish oil.
3. Vitamin C.
4. Magnesium citrate. The vast majority of Americans are magnesium deficient.
5. Niacinamide.
6. Zinc.
EDIT: Remove dosages to be in accordance with forum rules.
You want capsules, not tablets. Capsules dissolve.
If you want to know what each supplement does, and why you should be taking them, I suggest consulting a doctor or an online supplementation resource. The most important among these is the Vitamin D. Like most people here, I am somewhat of a recluse in the sense that I spend most of my time indoors. I believe there is a direct correlation between Vitamin D deficiency, caused by lack of exposure to Sunlight, and cholinergic urticaria.
There’s a couple points I want to stress.
1. The government RDA (Recommended Daily Allowance) is designed to prevent conditions such as rickets and scurvy for a population that can be drafted. These are far below the doses you need for optimum health.
2. You cannot compensate for a Vitamin D deficiency caused by lack of Sunlight through diet alone. The amount of Vitamin D you will get from food is insignificant compared to provision by the Sun.
3. You need to exercise, DAILY, regardless of the discomfort.
I will post a review of my success with this method in some months time.
Happy New Year and best of luck. Do not let your condition get you down in 2010.
EDIT: I want to add. You will need to make changes to your diet, in addition to the regular exercise and supplementation. Cut food items containing HFCS from your diet completely. Limit or completely eliminate processed foods from your diet. Eat more fruits and vegetables. If you drink or smoke, stop.
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Title: Re: Effective Supplementation for Cholinergic Urticaria
Post by: HivesGuy on January 05, 2010, 06:57:55 PM
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Hey whateverman,
First I just want to say thanks for the very informative post and welcome to the forum.j
I appreciate you offering your experience with Cholinergic Urticaria, as well as your thoughts and plans to help manage it.
I must say, I agree with a lot of what you said. I too seem to have a poor experience with most antihistamines, and find that any beneficial results soon go away as my body seems to adapt to the antihistamines within only days. They I just get itchy again just as bad.
As far as the diet, I totally agree that our food system is just about garbage. With all of the preservatives, irradiation, hormones, etc. etc. etc., I don’t see how it can NOT harm us in some way. I agree that eating a clean diet also usually improves symptoms. I know that when I eat totally clean & perfectly organic (avoiding junk/processed foods), my hives improve (but don’t go away) significantly.
Anyway, definitely keep us up to date with your experimentation with the supplements/diets. I am very interested to hear how you progress. Also, good luck in school, and I hope that the hives don’t drag you down.
Thanks again for the great post, and once again welcome =).
Hivesguy
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Title: Re: Effective Supplementation for Cholinergic Urticaria
Post by: kellie on January 21, 2010, 02:02:40 PM
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Hello All,
This is my first time on the forum. I have been dealing with hives for all my life. I am 44. I had them when I was little on my feet when I went out in the snow. Never chronic when I was very young. Chronic started when I was 15. They would like for about 3-5 months and come around every 3-4 years. Well it has been three years and they came back this last Oct. I have been to so many specialists, hypnothesis, doctors, Naturopathics, accupuncture. You name it I probably done it.
For some reason my body goes through this every 3-4 years and never know why. 20 years ago I did have a allergy skin test done through an allergist and then a blood allergy test done (RAST) thru a naturopathic dr. I avoid foods that were on the list only during my hive episodes. Otherwise they don’t bother me. My allergist tells me that because the tests were taken during an active episodes it was indicating that I was allergic when I probably have a intolarance. However it does help during my hive episodes to avoid the foods on the lists.
I just to let everyone know be careful of suppliments. Right now you body is very, very sensensitive. It will sometime react to new things entering it.For example..Vitamin D supplements seem to make my hives worse. It could be the most of them are made from Wool. Wool sweaters always make me itch.Try one supplement at a time. If your hives does not get worse for three days then you might be ok.To be on the safe side I don’t take any during my hive episode time. I found that they sometimes make it worse. I found out that exercise does help. 4 years ago my episode went away when started a daily walking outside. I also recommend going out side for an 1/2 hour if it is nice out. I am now going back to exericize and it is helping alot.
Exercise produces natural Adreline which is a natural cure.
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Title: Re: Effective Supplementation for Cholinergic Urticaria
Post by: kellie on January 22, 2010, 10:19:24 AM
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Me again.
Well I did great all day after exercising. I did not have hives again until this morning. I was wondering why??? I ate really healthy. However I did have a Krispee (marshmellow treat made with Krispee Cereal). I look on the box and behold…Vitamin D was added to the cereal. I don’t know if that was the culprit but I am going to make a note in my journal. Oh I also recommend you start a journal when you hives start. I wish I would of the last episodes.
I also want to make a note of what I take for medication (please note that generic do work but I would go for the original if hives are bad). It is considered the a hive/allergy cocktail by allergists.
Morning: 1 claritan and 1 Zantac (150)
Night: 1-2 Zrytec, 1-2 amitrypline (10mg) (antidepressant but helps hives and headaches)
If I plan to have a alcohol I take a pepcid about 1-2 hours beforehand. My sister in law is asian and this helps her not to turn red or heat up like most asians who drink alcohol.
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Title: Butterbur, Vitamin C, B100 complex instead of antihistamine?
Post by: Tokyowoman on January 29, 2011, 12:55:22 PM
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*** Butterbur
One article I read says the herbal supplement called “Butterbur” helps fight against allergies.
The article also says:
“study published in the British Medical Journal reported that butterbur treated seasonal allergies nearly as well as the prescription medication Zyrtec.”
Anyone tried Butterbur?
I’m worried about taking herbal supplement in general, but this one seems interesting. I’ll need to read the side effect also.
If you are interested in the details, you can search the internet with the key word, “butterbur allergies”.
Sorry, I don’t know much about it yet. I just wanted to share the info.
**** Vitamin C & B100 complex
I also read that they are supposed to help allergies.
Here’s what I have been trying.
Mon: one Centrum tablet + one Vit c tablet (500mg)
Tue: one B100 complex tablet + one Vit C tablet
Wed: one Centrum tablet + one Vit c tablet
Thur: one B100 complex tablet + one Vit C tablet
Fri: one Centrum tablet + one Vit c tablet
Sat:one B100 complex tablet + one Vit C tablet
Sun:one Centrum tablet + one Vit c tablet
I’ll try one more month and share the result with you :).
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Title: Re: Butterbur, Vitamin C, B100 complex instead of antihistamine?
Post by: Rogerq23 on February 02, 2011, 01:11:47 AM
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It sounds interesting, I still deciding which vitamin supplement should I buy since i finished my B-12 vitamins. Now I am currently taking vitamin C. I do use antihistamine though.
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Title: Re: Butterbur, Vitamin C, B100 complex instead of antihistamine?
Post by: demonsblood on February 05, 2011, 12:18:47 PM
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Hey guys,
I am trying to gym to the gym and during that process I was told to take the “usual” items such as protein shakes and multivitamin. I have pin pricks and hives whenever I get hot (from running, being in a hot place, being embarrassed) so I concluded that it is most likely cholinergic urticaria. Good news is that the multivitamin decreased the pin prick sensation substantially.
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Title: Re: Butterbur, Vitamin C, B100 complex instead of antihistamine?
Post by: HivesGuy on February 10, 2011, 09:11:13 AM
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I have been taking a multivitamin lately too, and at first I thought it was doing nothing. But I seem just a bit less reactive. I still get hives, but I am not quite as reactive. So I am definitely going to keep it up.
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Title: Cloves for Cholinergic Urticaria Hives?
Post by: nowash on February 12, 2011, 11:39:14 PM
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Hey guys, how’s the hives?
So I’ve been digging through PubMed a bit (ignoring my studies ;D), looking for new ways to attack the hives. Recently I’ve searched for what causes mast cells to trigger apoptosis (commit suicide), and one of the things that came up was eugenol*, a major constituent of clove oil. I had some cloves already so I decided to try and eat some, and it seemed to help. It at least helped me breathe and sweat, and when I did sweat I didn’t notice or feel any hives.
There are a couple ways I found that cloves could be helping:
1. 5-LOX/leukotriene inhibitor, almost how singulair works for asthma
2. TRPV (heat sensing receptor) interactions
3. Aforementioned mast cell inhibiting properties
If you guys want to try it, take precautions as I have read that eugenol can be toxic and cause liver damage and a bunch of other stuff. But dentists use the stuff as an anesthetic and for tooth fillings so maybe it’s safe? It also is a common allergic trigger, akin to aspirin or garlic etc.
*References:
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Apoptosis. 2005 Jan;10(1):193-200.
Phospho-ser 15-p53 translocates into mitochondria and interacts with Bcl-2 and Bcl-xL in eugenol-induced apoptosis.
Park BS, Song YS, Yee SB, Lee BG, Seo SY, Park YC, Kim JM, Kim HM, Yoo YH.
Department of Oral Anatomy and Cell Biology, Pusan National University College of Dentistry, Busan, South Korea.
Abstract
Our previous studies demonstrated that antiallergic effects of herbs such as clove and Magnoliae Flos (MF) resulted from the induction of apoptosis in mast cells. We here examined whether the antiallergic activity was caused by eugenol (4-allyl-2-methoxyphenol) which was one of major ingredients in the essential oils or extracts of numerous plants including clove and Magnoliae Flos. RBL-2H3 cells were treated with eugenol, and DNA electrophoresis, Western blotting, immunocytochemistry, confocal microscopy and immunoprecipitation were conducted. Effect of eugenol was tested using a rat anaphylaxis model. RBL-2H3 cells treated with eugenol showed typical apoptotic manifestations and translocation of p53 into mitochondria. Antisense p53 partially prevented the induction of apoptosis. Noticeably, we observed that p53 translocated into mitochondria was phosphorylated on ser 15. Phospho-ser 15-p53 physically interacted with Bcl-2 and Bcl-xL in mitochondria and its translocation into mitochondria preceded cytochrome c release and mitochondrial membrane potential (MMP) reduction. We also depicted that the survival of animals even after administration of the fatal dose of compound 48/80 might result from the decreased number of mast cells by eugenol pretreatment. In conclusion, eugenol induces apoptosis in mast cells via translocation of phospho-ser 15-p53 into mitochondria.
PMID: 15711935 [PubMed – indexed for MEDLINE]
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Pharmacol Res. 1997 Dec;36(6):475-80.
Antianaphylactic properties of eugenol.
Kim HM, Lee EH, Kim CY, Chung JG, Kim SH, Lim JP, Shin TY.
Department of Oriental Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea.
Abstract
The effects of eugenol, a major component of clove, on anaphylaxis were evaluated in rats. Eugenol inhibited compound 48/80-induced systemic anaphylaxis 100% with a dose of 10 micrograms g-1 body weight (BW). While serum levels of histamine were markedly elevated after compound 48/80 injection in all groups of rats, rats injected with eugenol showed a significant reduction in serum histamine levels. Eugenol also inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. Eugenol dose-dependently inhibited histamine release from the rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The morphological examination clearly showed that eugenol prevented the anaphylactic degranulation of RPMC. Moreover, Eugenol (10 micrograms ml-1) had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-alpha production. These results suggest that eugenol has antianaphylactic properties by preventing mast cell degranulation.
PMID: 9508673 [PubMed – indexed for MEDLINE]
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Title: Re: Cloves?
Post by: nowash on February 13, 2011, 06:05:13 AM
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Just realized I put this in the wrong forum…
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Title: Re: Cloves?
Post by: HivesGuy on February 16, 2011, 03:24:10 PM
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Hey nowash,
Thanks for neglecting your studies to update us with some Cholinergic Urticaria info ;). I went ahead and moved this post to this new board for you.
It is definitely interesting to consider, and interesting that it seemed to maybe help you a bit. Definitely keep us posted if you continue taking this, although I would definitely be cautious and talk to a doctor about it.
It kinds sounds similar to the “histamine reduction” ideas we have had lately, but so far that hasn’t worked out for me at all. But it would be nice if something like this did work.
Thanks again for posting all of your research and ideas.
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Title: Re: Cloves?
Post by: AdamM on February 16, 2011, 09:46:41 PM
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It sounds like it may be a solution too bad about the possible side effects though. I’ll just wait out and see just because with my luck i’ll end up in a worse boat than i’m in already.
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Title: Re: Vitamins for Cholinergic Urticaria?
Post by: Pyridoxal on April 28, 2011, 11:18:13 AM
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I use a high dose of vitamin B6 (pyridoxine + p-5-p) together with a B-100 complex and magnesium. I’ve found this to be a very effective treatment for my c u.