I was diagnosed with cholinergic urticaria when I was a freshman in high school. After going to the dermatologist all they told me to take was Benadryl which helped with the itching a little but that was it. So after doing a ton of research on it (along with the help of my dad… have to give him credit) I finally discovered a mix of three drugs that ended up completely getting rid of my symptoms and may have completely cured me (not sure if it cured it because I started tapering off the medication two years later around the time that it could start going away on its own).
I started taking one Claritin, one Pepcid AC, and two super Quercetin every night. I had to take it every single night for about a month and then my symptoms disappeared. But if I missed just one pill for one night then my symptoms would return and it would take another month to completely get rid of my symptoms again. But I did this for about two years and started tapering off my medication one pill at a time (starting with one quercetin, then the next, then the Pepcid, and then the Claritin) and I haven’t had an outbreak since then (six years later).
I just finished my second year of pharmacy school and was motivated to become a pharmacist because of this disease in order to understand how this could work and to educate other people like me. All three of these drugs block different histamine receptors in your body that results in the production of hives (Quercetin is natural and its mechanism isn’t widely known but somehow it works – also I’m not sure what the difference of quercetin vs. super quercetin would be but that’s what I used).
(Note: Please talk to your doctor before trying antihistamine combinations or other medications / supplements, as they may not be safe or appropriate for all individuals).