Phosphatidylserine
Post by: hieveryone on April 05, 2011, 10:58:47 AM
Hi people,
Do you know a suplement called Phosphatidylserine (this is the name of the principle, not the trade mark)? It’s used to many things, but mainly to reduce cortisol. It’s safe (in normal doses) and doesn’t need prescription, I think it might be interesting to give it a try, did any of you take it before? it would be great to know some oppinions, thanks in advance…
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Title: Re: Phosphatidylserine
Post by: Darkhorse on April 11, 2011, 11:00:03 AM
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Sure worth checking out
“higher serum cortisol concentrations in chronic idiopathic urticaria patients. The basophil response to CRF and ACTH correlated with the serum cortisol concentration in normal controls, but not in CIU patients.
CONCLUSIONS: Although our data have not supported the hypothesis that stress makes a major contribution to CIU, the heightened basophil response to CFR and ACTH and higher levels of serum cortisol do suggest a derangement of the HPA axis in CIU.”
Clin Exp Allergy. 2008 Jan;38(1):86-92. Epub 2007 Nov 1.
Yet another to add to my test list!
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Title: Re: Phosphatidylserine
Post by: hieveryone on April 11, 2011, 01:01:44 PM
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Thanks for the reply Darkhorse,
I bought a supplement but it took only 300 mg of IP-20 and on the prescription told something about 20% (I don’t know if it has only 20% of these 300mg or 20% added plus the soya extract) and other vitamins to ‘Improve your studies’, anyway, I took that one becouse it was made here in Spain so it costed around 15 euros (20 dolar) and the real Phosphatidylserine supplement costed 75 euros. Curiosly I got a hard flu the second day of taking it (and it’s really hot in this April) and this weekend I stopped becouse of the flu, today night I will begin again. I’ve also bought some omega3 capsules, I read that they were good for Cortisol.
Anyway, I think the dose is low, I will try to ask for a medical discount for the Phosphatidylserine , I’ve read that you need doses of 700 mg to start to feel the effects of decreasing cortisol, and that is safe taking it. I’ve read that people who work out a lot take it to stop the cortisol eat their muscles. I’m a very skinny man so I may have high cortisol levels, and also my Cholinergic Urticaria appeared when I was working out a lot (when you work out you can produce a lot more cortisol). What do you think about this?, well, thanks for the read!
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Title: Re: Phosphatidylserine
Post by: Darkhorse on April 11, 2011, 06:09:59 PM
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Indeed cortisol levels explode when exercising especially with a stressor such as resistance training. Exercise forces the body to deviate temporarily from homeostasis (natural set-point), it is perceived as a stress and causes the release of cortisol. However, regular exercise training will decrease this effect, causing the body to have a better response to stress and require less cortisol release
I’m under the opinion that Cholinergic Urticaria is 100% a result of a histamine hypersensitivity reaction as a result of an increase in the weighted average body temperature. In Cholinergic Urticaria it’s just a matter of what causes that hypersensitivity and how we can restore the balance. Which is yet to be established as to why we develop this condition in the first place.
Although I don’t think cortisol has a direct role in the cause of the problem, I do think that controlling the derangement of the HPA axis through the use of phosphatidylserine to suppress cortisol is important. The hypothalamus axis is such an in-dept area and it control’s so many functions in the body I think it is worth doing everything in your power to maintain equilibrium epically in us with histamine imbalances due to unknown reasons.
Just to let you know soy is not something you wanting to be taking in excess unless your a female as it a plant estrogen which can convert into bio-available estrogen in the body which can offset testosterone function in males.
I think you mentioned fish oil in the form of omega-3, I would recommend you look into omega-6 in the form of linoleic acid as it is used to regulate the immune system which I feel is more important than cortisol suppression.
Keep us posted if you notice any results
– Darkhorse